In 1956, when he began working with a small group
in a Boston laboratory, measles was a major threat. Seven years later,
lifesaving immunizations began.
Dr. Samuel L. Katz, a virologist who was part of the research
team at Harvard Medical School that developed the measles vaccine, an advance
more than half a century ago that has saved countless lives, died on Monday at
his home in Chapel Hill, N.C. He was 95.
His son David confirmed the death.
Dr. Katz later enhanced the reputation of the pediatrics department at the Duke
University School of Medicine as its chairman.
Dr. Katz took up the fight against measles in 1956, when he joined a laboratory
at Children’s Hospital Medical Center (now Boston Children’s Hospital) run by
Dr. John Enders. Two years earlier, Dr. Enders had shared the Nobel Prize in
Physiology or Medicine for discovering how to grow the polio virus in cultures,
a breakthrough that was critical to Jonas Salk’s development of a polio vaccine,
which led to widespread successful immunizations.
Dr. Enders’s lab had already isolated the measles virus from a 13-year-old boy
when Dr. Katz arrived there as a research fellow. Measles was a major medical
threat at the time: In the decade before the vaccine was made available in 1963,
nearly every child in the United States had measles by age 15, with three to
four million people infected by it every year, leading to an estimated 400 to
500 deaths annually, according to the Centers for Disease Control and
Prevention.
Worldwide, measles killed 2.6 million people a year before the availability of
vaccines, the World Health Organization said.
“I was put to work with a visitor from Yugoslavia, Milan Milovanovic, who taught
me a lot of practical, at-the-bench work,” Dr. Katz told Dartmouth Medicine, an
alumni magazine, in 2009. “We worked together on adapting the virus to different
cell systems and to eggs and eventually to chick embryo cells” — a process that
led to the weakening of the virus so it could stimulate an immune response
without causing serious side effects.
Dr. Katz was involved in inoculating rhesus monkeys with the virus.
“And when we put the chick virus into monkeys, they didn’t develop viremia” — a
virus in the blood — “they didn’t develop fever, they didn’t develop any sort of
nasal congestion or conjunctivitis or rash, they were perfectly fine,” he said
on the podcast “Open Forum Infectious Diseases” in 2014. “But they developed
antibodies.”
The chick virus was injected into students at a state school for children with
neurological and central nervous system problems, a group whose use by the lab
reflected a time of looser ethical standards about test subjects.
“At the end of several weeks, they had antibodies to the measles virus,” Dr.
Katz recalled.
He became a research associate in the lab in 1958 and kept that title for the
next decade, during which he was also a pediatrician at Children’s Hospital and
Beth Israel Hospital in Boston and an assistant professor of pediatrics at
Harvard Medical School.
Dr. Katz played two other notable roles in the development of the measles
vaccine. In one, he worked with pharmaceutical firms that wanted to manufacture
a vaccine.
“He was forever sending vials of the viruses to Merck and other companies,” I.
George Miller Jr., a professor of pediatrics at the Yale School of Medicine, who
joined the lab in 1961, said in a phone interview. “He was kind of the Good
Humor man for vaccines.”
In the other role, at the request of a British pediatrician, David Morley, Dr.
Katz brought a prototype vaccine to Nigeria in 1961 to immunize children who
were highly susceptible to measles because their systems had been weakened by
malaria, intestinal worms, vitamin A deficiency and protein depletion.
Nigerian parents were accustomed to losing their children to measles; they had a
mortality rate of 5 to 15 percent if they got the virus. While there, Dr. Katz
recalled on the “Open Forum” podcast, he heard people say, “You don’t count your
children until the measles has passed.”
He vaccinated children in a village there, and they developed immunity.
The measles vaccine was licensed in 1963 and soon became widely available; eight
years later, it was incorporated into the combined measles, mumps and rubella
vaccine.
Samuel Lawrence Katz was born on May 29, 1927, in Manchester, N.H. His father,
Morris, was a railroad executive; his mother, Ethel (Lawrence) Katz, was a
homemaker.
He entered Dartmouth College in 1944, hoping to become a journalist. His
interest changed to medicine a year later, when he enlisted in the Navy and was
sent to hospital training school in San Diego.
He returned to Dartmouth after the war and earned a bachelor’s degree in
political science in 1948. He also took the pre-med courses required to enter
Dartmouth’s medical school, a two-year school then. He graduated with a
bachelor’s in medical science in 1950 and from Harvard Medical School in 1952.
After interning at Beth Israel, he was a resident at Children’s Hospital, a
teaching affiliate of Harvard Medical School. While there, he witnessed a polio
outbreak in the summer of 1955, the year the Salk vaccine became available.
He worked in the hospital’s polio wards that summer, seeing the disease’s
devastation firsthand. When the crisis eased, he asked for permission to work
with Dr. Enders.
“All the time we were working in the lab — with viruses, with cell cultures,
with blood specimens, with potential vaccines,” Dr. Katz said on the podcast,
Dr. Enders “would give these materials to anyone that visited the lab who was a
legitimate investigator.”
Dr. Katz left Harvard for the Duke University School of Medicine in 1968. As
chairman of its pediatrics department for 22 years, he helped raise its national
standing.
“He had such a command of virology and clinical practice and was engaging in a
very positive way,” Dr. Mary Klotman, dean of the Duke medical school, said in a
phone interview. “He was a role model for the integration of science, clinical
care and mentoring the next generation of clinicians.”
Dr. Katz stepped down from running the Duke pediatrics department in 1990 to
work with his second wife, Dr. Catherine Wilfert, an H.I.V./AIDS researcher and
activist and professor of pediatrics at the Duke medical school. She was the
principal investigator in a pediatric AIDS clinical trial, beginning in 1987,
that showed the efficacy of using the drug AZT to reduce the incidence of
mother-to-child transmission of H.I.V. by over 60 percent.
Dr. Wilfert left Duke in 1996 and became scientific director of the Elizabeth
Glazer Pediatric AIDS Foundation. Dr. Katz continued to teach at Duke until
retiring in 1997.
In addition to his son David, he is survived by two other sons, John and
William; five daughters, Deborah Miora, Susan Calderon, Penelope Katz Fischer,
Rachel Wilfert and Katie Regen; and 17 grandchildren. His marriage to Betsy
Cohan ended in divorce. His marriage to Dr. Wilfert ended with her death in
2020. His son Samuel Jr. died in 1980.
Dr. Katz became a renowned advocate for vaccines. He was chairman of the
C.D.C.’s advisory committee on immunization practices from 1985 to 1993 and the
recipient of the 2003 Albert B. Sabin Gold Medal, which is given to public
health leaders who save lives through vaccines. The medal is named for the
doctor who developed the oral polio vaccine.
“He was someone you could count on for intellectual rigor, who never panicked
and wanted to do what was best in the field,” Peter Hotez, dean of the National
School of Tropical Medicine at the Baylor College of Medicine, said in an
interview. He added, “I’m sure he would have conniptions over the anti-vaccine
activism causing people to refuse the Covid vaccine.”
Richard Sandomir is an obituaries writer. He previously wrote about sports media
and sports business. He is also the author of several books, including “The
Pride of the Yankees: Lou Gehrig, Gary Cooper and the Making of a Classic.”
Samuel L. Katz, a Developer of the Measles Vaccine, Dies at 94 In
1956, when he began working with a small group in a Boston laboratory, measles
was a major threat. Seven years later, lifesaving immunizations began.,
NYT,
Nov. 5, 2022, 12:39 p.m. ET,
https://www.nytimes.com/2022/11/05/
health/samuel-katz-dead.html
