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Bacterial diseases

Typhus

Typhus

Typhoid fever is a bacterial infection

that can spread throughout the body,

affecting many organs.

Without prompt treatment,

it can cause serious complications

and can be fatal.

It's caused

by a bacterium called Salmonella typhi,

which is related to the bacteria

that cause salmonella food poisoning.

Typhoid fever is highly contagious.

An infected person can pass

the bacteria out of their body

in their poo (stools) or,

less commonly, in their pee (urine).

If someone else eats food or drinks water

that's been contaminated

with a small amount of infected poo or urine,

they can become infected with the bacteria

and develop typhoid fever.

Who's affected?

Typhoid fever is most common in parts of the world

that have poor sanitation and limited access to clean water.

Worldwide, children are thought

to be most at risk of developing typhoid fever.

This may be because their immune system

(the body's natural defence against infection and illness)

is still developing.

But children with typhoid fever

tend to have milder symptoms than adults.

Typhoid fever is uncommon in the UK,

with an estimated 500 cases occurring each year.

In most of these cases,

the person developed the infection

while visiting relatives in Bangladesh, India or Pakistan.

But you're also at risk of developing the infection

if you visit Asia, Africa or South America.

How typhoid fever is treated

Typhoid fever requires

prompt treatment with antibiotics.

If typhoid fever is diagnosed early,

the infection is likely to be mild

and can usually be treated at home

with a 7- to 14-day course of antibiotic tablets.

More serious cases of typhoid fever

usually require admission to hospital

so antibiotic injections can be given.

With prompt antibiotic treatment,

most people will start

to feel better within a few days

and serious complications are very rare.

Deaths from typhoid fever

are now virtually unheard of in the UK.

If typhoid fever isn't treated,

it's estimated that up to 1 in 5 people

with the condition will die.

Some of those who survive

will have complications

caused by the infection.

Typhoid fever vaccination

In the UK,

2 vaccines are available

that can provide some protection

against typhoid fever.

These involve either having a single injection

or taking 3 capsules over alternate days.

Vaccination is recommended

for anyone planning to travel to parts of the world

where typhoid fever is widespread.

It's particularly important

if you're planning to live or work

closely with local people.

But as neither vaccine

offers 100% protection,

it's also important to follow

some precautions when travelling.

For example,

you should only drink bottled or boiled water,

and you should avoid foods

that could potentially be contaminated.

https://www.nhs.uk/conditions/typhoid-fever/ - September 3, 2020

https://www.nhs.uk/conditions/typhoid-fever/ - September 3, 2020

https://www.npr.org/sections/goatsandsoda/2020/09/02/
908732924/the-warsaw-ghetto-can-teach-the-world-how-to-beat-back-an-outbreak

The Warsaw Ghetto

Can Teach The World

How To Beat Back An Outbreak

September 2, 2020

5:12 PM ET

NPR

Alex Hershaft remembers the special comb.

He and his family were living in the Warsaw ghetto. It was 1940. He was a little boy, about 6 years old.

A disease known as epidemic typhus was spreading among the close to half a million Jews confined in 1.3 square miles of Warsaw, Poland, in what became known as the Warsaw ghetto.

Records kept by ghetto leaders and unearthed after World War II show six or more people lived in a single room in some apartments. Many homes had no running water, and there were few public baths, according to records from the U.S. Holocaust Memorial Museum in Washington, D.C., and Yad Vashem, the World Holocaust Remembrance Center in Jerusalem.

Typhus is a highly contagious bacterial disease carried by body lice, which thrive in cramped and unsanitary conditions. It can cause fever, chills, body aches, coughs, nausea and confusion. In outbreaks during World War I, the death rate was 10% to 40%. And there was no antibiotic treatment until the drug doxycycline was approved for marketing by the U.S. Food and Drug Administration in 1967.

But the Jews of the Warsaw ghetto beat back typhus. And the comb was one of their weapons.

The comb has "very fine teeth to comb out your hair" — and catch any lice, says Hershaft, now 86 and living in Bethesda, Maryland.

The squelching of that outbreak of epidemic typhus in the Warsaw ghetto is the subject of a new study, which is especially relevant in a world battling the coronavirus pandemic.

The study, published in July, suggests that public health measures such as social distancing, hygiene and food supplies to supplement the meager rations provided by the Nazis could have been responsible for an unexpected drop in typhus cases in the winter of 1941.

The Nazis established the ghetto within the city of Warsaw in November 1940 and began herding in both Polish and refugee Jews.

According to the study, "there was a fanatical fear of typhus spreading to the German people and its army, given its previous impact as the cause of 5 million deaths after WWI. This was the pretense given by the Germans for the relocation of Jewish victims en masse into isolated closed ghettos and camps in wartime Europe."

Even though that pretext was false, typhus did in fact sweep through the Warsaw ghetto, sparked by the living conditions and worsened by the lack of food. By 1941, official food rations for Jews were under 200 calories per day, according to a 1992 book, Courage Under Siege: Starvation, Disease, and Death in the Warsaw Ghetto, by Charles G. Roland, a physician and historian. A lack of nutrition can make it harder for a person's immune system to fight off disease.

Hershaft says he remembers people in the ghetto looking for food and neighbors giving clothes and other possessions to his grandparents' Russian housekeeper, who remained with his family during their time in the ghetto. Unlike the Jewish residents of the ghetto, she could leave its confines and would exchange the goods for food she would bring back.

Two major waves of the typhus epidemic hit the Warsaw ghetto: one in 1940 soon after the enclave was erected and another in early 1941. "The official number of monthly reported new typhus cases for both epidemic waves sums to a total of 20,160 reported cases," write the authors of the study. "Yet, according to the scattered reports of leading epidemiologists of the ghetto, there is reasonable consensus that a total of 80,000 to 110,000 residents were infected."

But that number may have amounted to only 20% to 25% of actual cases, according to the study, "likely because many of the Jews may not have reported having typhus for fear they'd be killed by the Nazis or otherwise punished."

Lewi Stone, the study's lead author and a professor of biomathematics at RMIT University in Melbourne, Australia, as well as at Tel Aviv University, says the discrepancy can be seen from referring to documents collected in the ghetto, particularly those from what is known as the Ringelblum Archive, a treasure trove of documents gathered and hidden during the ghetto years and named for Emanuel Ringelblum, a social activist and historian who created and led the archive project. Ringelblum's archives were hidden in metal cases and milk cans beneath the streets of the ghetto; two of the three troves were discovered after the war.

Stone says to learn more he "spent many, many hours in libraries around the world seeking rare documents or publications to find details about the interventions employed." Among the works he consulted were the records and memoirs of Ludwik Hirszfeld, a well-known bacteriologist who, with his family, was sent to the ghetto in 1941, where he was involved in medical care. He escaped in 1943 and died in 1954.

According to the study, an unexpected development occurred during the second typhus wave, and "unusually, in late October 1941, just at the onset of winter, the typhus epidemic rapidly began to curtail and collapse.

"The epidemic's 'turnaround' was completely unexpected since typhus infection normally accelerates during winter," say the study authors. Ringelblum was the source of that information. They quote him as saying: "The typhus epidemic has diminished somewhat—just in the winter, when it generally gets worse. The epidemic rate has fallen some 40 per cent. I heard this from the apothecaries, and the same thing from doctors and the hospital."

The study authors used mathematical modeling techniques to investigate whether that drop came because the typhus outbreak "burned itself out" naturally or whether these external interventions assisted, says Stone.

"We could see from this drop that something had to be blocking disease transmission pathways," says Stone. "For modelers, this is the telltale sign of behavioral interventions. Indeed, we know that in other towns of the region, typhus continued on through the winter unabated."

The study's conclusion, according to Stone: "It was odd that just in the Warsaw ghetto the disease should die out before winter when it was expected to accelerate," said Stone. "Thus, we are fairly confident that the [public health] intervention succeeded."

What specific measures could account for the drop? The study ticks off several:

More food. The Nazis began seeing some ghetto residents as potential workers and increased food aid in the ghetto and briefly allowed food smugglers to bring in rations. In addition, community soup kitchens were set up and provided food for some 100,000 residents, funded with money smuggled into the ghetto by an American Jewish aid group, the Joint Distribution Committee, and coordinated by ghetto leaders, including Ringelblum.

Public health efforts. The community's network of social, self-help and medical organizations was intensely involved in fighting the epidemic, with public courses on public hygiene and infectious diseases often attended by more than 900 people at a time. There were also home-cleaning programs by self-governing bodies in the ghetto with the goal of eradicating typhus. In addition, an underground university was set up to train medical students, and scientific studies on the phenomenon of starvation and epidemics were conducted.

Personal responsibility: Building and apartment cleanliness was encouraged and often enforced through inspections by members of the Jewish council in the ghetto.

The impact of social interventions is plausible to Patricia Heberer-Rice, director of the division of the senior historians at the U.S. Holocaust Memorial Museum, who says that both the Warsaw and Lodz ghettos, also established by the Nazis, "had strong social organizations, public health campaigns, lectures on hygiene and policing themselves for lice."

But at least two historians of the ghetto are not completely convinced of the study's conclusions that hygiene, food and public health efforts could have been the key reasons that typhus cases dropped in the Warsaw ghetto in 1941. "I don't think social distancing measures could have played a major role, because of the extreme overcrowding of the ghetto streets," says Samuel Kassow, a professor of history at Trinity College and author of Who Will Write Our History?, about Ringelblum's archive.

"But a drive to improve sanitation in buildings may have played a role," says Kassow. He quotes the leading epidemiologist in the ghetto, Ludwik Hirszfeld, who survived the war and wrote: "We tried to ensure that outbreaks centered in specific buildings and apartments ebbed spontaneously. We didn't spread the epidemic by taking totally inappropriate measures. I don't think however that this was the only reason for the decline. But public opinion ascribed the improvement to the new leadership and the new spirit in the Health department."

Professor Miriam Offer, a prominent researcher on medicine in the Warsaw ghetto and a lecturer at Western Galilee College and Tel Aviv University on medicine during the Holocaust, also questions whether the number of typhus cases could have just simply fallen so steeply. In her book, White Coats in the Ghetto, Offer says it is likely that there were reasons beyond the public health measures that the number of typhus cases dropped — including herd immunity. So many people contracted typhus that its ability to spread diminished, she theorizes, drawing from the writings of Hirszfeld.

But the value of the study, especially as it may relate to the coronavirus, may not lie in whether the authors can prove irrefutably how typhus was brought under control. "For people living in the ghetto, despite so many odds stacked against them, the will to live was very strong, so to take measures to try to prevent typhus, to keep the population as healthy as possible, is fabulous," says Heberer-Rice.

Aaron Glatt, chief of infectious diseases at Mount Sinai South Nassau hospital on Long Island, N.Y., and a spokesman for the Infectious Diseases Society of America, says he suspects "that a combination of many factors, including both efforts to actively prevent spread coupled with many people being immune by the virtue of having had disease and getting better both played a role in the sudden arrest of the spread of disease."

Glatt, the associate rabbi of a synagogue on Long Island, has a personal connection to the Warsaw ghetto and to typhus. His paternal grandmother died in the Warsaw ghetto, he says, and "my aunt died of typhus in my mother's arms on the day Auschwitz was liberated."

Glatt believes that the Warsaw ghetto experience has much to teach the world as it struggles to deal with COVID-19. "The level of desire and commitment to address a public health issue is the most important characteristic as to whether you will be successful," says Glatt. "If you don't take things seriously enough and don't have the desire to beat it, people will die."

Alex Hershaft has a similar perspective. His own family, he says, was "somewhat fortunate" because his maternal grandparents had a large home in the ghetto where his family moved and had money and goods of value to trade for food outside the ghetto.

"I don't think anyone in my family contracted lice," said Hershaft, who says he sees parallels with the coronavirus now. "People who could afford to stay home and had enough to eat were OK, and people who had to mingle with others and didn't have enough to eat were the most likely victims."

And like Glatt, Hershaft speaks of the strong will to live in the ghetto: "People were keenly aware of their mortality, which is what made them go to such lengths to try to prevent typhus."

"Now," says Hershaft, "some people don't take COVID seriously because the concept of contracting a deadly disease is so foreign to us, while in the ghetto, we were so conscious that the next day could be our last."

The Warsaw Ghetto Can Teach The World How To Beat Back An Outbreak,
NPR,
September 2, 2020
https://www.npr.org/sections/goatsandsoda/2020/09/02/
908732924/the-warsaw-ghetto-can-teach-the-world-how-to-beat-back-an-outbreak
 

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